Apoquel is an oral medication used in dogs to control itching and inflammation associated with allergic and atopic dermatitis. It works by selectively inhibiting Janus kinase 1 (JAK1) enzymes, which are involved in the signaling pathways that cause itch and inflammation. Apoquel provides rapid relief—often within 4 hours—and is safe for long-term use under veterinary guidance. It is particularly effective in managing chronic allergy-related skin conditions.