Clotrimazole oral troches are used for the local treatment of oropharyngeal candidiasis. Oropharyngeal candidiasis is a fungal infection in the mouth and throat caused by an overgrowth of the Candida fungus. They are also used to reduce the incidence of oropharyngeal candidiasis in immunocompromised patients undergoing chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation.