Estradiol (estrogen) is a female hormone used to help alleviate symptoms of menopause, including vaginal dryness, burning, and painful intercourse. Estradiol oral tablets are FDA-approved to treat vulvar and vaginal atrophy associated with menopause. Vaginal atrophy (atrophic vaginitis) is thinning, drying and inflammation of the vaginal walls that may occur when your body has less estrogen. They’re also FDA approved to treat vasomotor symptoms associated with menopause.