Gemfibrozil is prescribed to help reduce triglyceride levels and increase high-density lipoprotein (HDL) cholesterol in the blood. It may also contribute to lowering low-density lipoprotein (LDL) cholesterol. As a member of the fibrate class of medications, gemfibrozil functions by reducing the amount of fat produced by the liver. In individuals with extremely high triglyceride levels, it may also reduce the risk of pancreatitis. It’s used to lower the risk of coronary heart disease in certain people.