Lidocaine-prilocaine cream is a combination of two topical anesthetics (i.e. numbing medications) that is used to prevent pain or discomfort associated with injections. Topical anesthetics work by blocking nerve signals in the injected area and therefore preventing pain signals from reaching the brain. Lidocaine-prilocaine cream is used to prepare for minor surgery, cosmetic or medical procedures, including use on genital mucosa, and for pretreatment of infiltration anesthesia (numbing of a localized area). Procedures that may benefit from lidocaine-prilocaine cream include: Botox injections, skin biopsies, skin grafting, extensive dermabrasion, and plastic surgery. Lidocaine-prilocaine cream may also be applied prior to penile injections being used for erectile dysfunction.