Pimecrolimus cream is a topical immunomodulator used to treat mild to moderate atopic dermatitis (eczema) in patients who do not require or cannot tolerate corticosteroids. It works by inhibiting calcineurin, a protein involved in immune responses, thereby reducing inflammation, itching, and redness of the skin. Unlike corticosteroids, pimecrolimus does not cause skin thinning, making it a suitable long-term option for sensitive areas such as the face and neck.