Sacubitril/valsartan, the generic form of Entresto, is a prescription medication commonly used to treat heart failure with reduced ejection fraction (HFrEF). It combines two active ingredients: sacubitril, a neprilysin inhibitor that helps increase levels of beneficial peptides to improve blood flow and reduce fluid buildup, and valsartan, an angiotensin II receptor blocker (ARB) that lowers blood pressure by relaxing blood vessels. Together, they help reduce strain on the heart, improve its efficiency, and lower the risk of hospitalization and cardiovascular death in heart failure patients. This medication is typically taken twice daily and is part of a long-term treatment plan under the supervision of a healthcare provider.